Early postnatal ethanol exposure induces fluctuation in the expression of BDNF mRNA in the developing rat hippocampus

• Autorzy: Miki T. , Kuma H. , Yokoyama T. , Sumitani K. , Matsumoto Y. , Kusaka T. , Warita K. , Wang Z.-Y. , Hosomi N. , Imagawa T. , Bedi K. S. , Itoh S. , Nakamura Y. , Takeuchi Y.
• Języki publikacji: EN

Abstrakty

EN

Effects of early postnatal ethanol exposure on brain-derived neurotrophic factor (BDNF) mRNA expression in the rat hippocampus were investigated. Wistar rats were assigned to either ethanol treatment (ET), separation control (SC) or mother-reared control (MRC) groups. Ethanol exposure was achieved by a vapor inhalation method for 3 hours a day between postnatal days (PND) 10-15. On PND 16, 20, 30, and 60, the expression of BDNF mRNA in the hippocampus was determined using real-time RT-PCR analysis. There was a significant age-related increase in the BDNF mRNA expression between PND 30–60 in MRC animals. The BDNF mRNA expression in ET rats was increased at both PND 16 and 20 and thereafter decreased at PND 60 compared to SC animals. Such age-related fluctuation in the expression of BDNF mRNA differed from that of MRC animals. The exact functional implications, if any, of these ethanol-induced changes in BDNF mRNA expression remain unknown although it can be speculated that they may have an effect on the behaviors known to be influenced by the hippocampal formation.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2008
• Tom: 68
• Numer: 4
• Opis fizyczny: p.484-493,fig.,ref.

Twórcy

autor

Miki T.

• Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, Kagawa, Japan

autor

Kuma H.

• Department of Neuropsychiatry, Faculty of Medicine, Kagawa University, Kagawa, Japan

autor

Yokoyama T.

• Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, Kagawa, Japan

autor

Sumitani K.

• Department of Sports Physiology, Faculty of Medicine, Kagawa University, Kagawa, Japan

autor

Matsumoto Y.

• Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, Kagawa, Japan

autor

Kusaka T.

• Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan

autor

Warita K.

• Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, Kagawa, Japan

autor

Wang Z.-Y.

• Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, Kagawa, Japan

autor

Hosomi N.

• Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan

autor

Imagawa T.

• Department of Veterinary Anatomy, Faculty of Agriculture, Tottori University, Totton, Japan

autor

Bedi K. S.

• Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Australia

autor

Itoh S.

• Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan

autor

Nakamura Y.

• Department of Neuropsychiatry, Faculty of Medicine, Kagawa University, Kagawa, Japan

autor

Takeuchi Y.

• Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, Kagawa, Japan

Uwagi

PL

Rekord w opracowaniu