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2012 | 62 | 2 |
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Potential health benefits of bread supplemented with defatted flaxseeds under dietary regimen in normal and type 2 diabetic subjects

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Flaxseed is a rich source of dietary fi bers and lignans. Uncontrolled diabetes may induce complication represented by dyslipidemia, high oxidative stress and kidney dysfunction. In the present research the benefi cial effect of two months consumption of bread supplemented with defatted fl axseeds (DFB) together with dietary regimen was evaluated in normal and type 2 diabetic patients. Protective effect towards diabetic complications was studied through evaluation of plasma lipid profi le, lipid peroxidation, liver and kidney function. The nutritional status of normal and diabetic patients was evaluated through assessing body mass index and nutrients’ intake. Results showed reduction of body mass index in both normal and diabetic patients after nutritional intervention. Analysis of mean dietary intake of normal and diabetic patients in the beginning of the study revealed that all subjects were hyper- -caloric that reduced to be 79% and 84% from RDA, respectively after treatment. After two months of supplementation with DFB, diabetic patients showed signifi cant reduction of plasma glucose. Both diabetic patients and normal subjects showed signifi cant improvement in plasma lipid profi le and signifi cant reduction of lipid peroxidation. Consumption of DFB in addition of dietary regimen may be helpful in preventing diabetes and its complications.
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  • Food Sciences and Nutrition Department, National Research Centre, Dokki, Cairo, Egypt
  • 1. Al-Shamaony L., Al-Khazraji S.M., Twaij H.A.A., Hypoglycemic effect of Artemisia herba alba. II. Effect of a valuable extract on some blood parameters in diabetic animals. J. Ethnopharm., 1994, 43, 167–171.
  • 2. Amresh G., Kant R., Zeashan H., Gupta R.J., Rao C.H.V., Singh P.N., Gastroprotective effects of ethanolic extract from Cissampelos pareira in experimental animals. J. Nat. Med., 2007, 61, 323−328.
  • 3. Anuradha C.V., Selvam R., Effect of oral methionine on tissue lipid peroxidation and antioxidants in alloxan-induced diabetic rats. J. Nutri. Biochem., 1993, 4, 212−217.
  • 4. Assmann G., Nofer J., Atheroprotective effects of high-density lipoproteins. Ann. Rev. Med., 2003, 54, 321−341.
  • 5. Atwal A.S., Kubow C., Wolynetz M.S., Effect of protein source and amino acid supplementation on plasma cholesterol in guinea pig. Int. J. Vitam. Nutr. Res., 1997, 67, 192–195.
  • 6. Bray G.A., What is the ideal body weight? J. Nutr. Biochem., 1998, 9, 489–492.
  • 7. Burstein M., Scholnick H.R., Morfi n R., Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J. Lipid Res., 1970, 11, 583–95.
  • 8. Chung M.W.Y., Isolation and characterization of the major fraction of fl axseed proteins. 2001, MSc. thesis, The University of British Columbia, Vancouver, BC, Canada, p. 75.
  • 9. Duckworth W.C., Hyperglycemia and cardiovascular disease. Curr. Ather. Rep., 2001, 3, 381–391.
  • 10. FAO/WHO. Food and Nutrition Board. Nutritional Research Council. Recommended Dietary Allowances, 1989, 10th ed. Washington DC. National Academy Press.
  • 11. Fukuda Y., Osawa T., Namiki M., Ozaki T., Studies on antioxidative substances in sesame seed. Agric. Biol. Chem., 1985, 49, 301−306.
  • 12. Goldberg I.J., Clinical Review 124. Diabetic dyslipidemia: causes and consequences. J. Clin. Endocr. Met., 2001, 86, 965–971.
  • 13. Gupta A.K., Ross E.A., Myers J.N., Kashyap M.L., Increased reverse cholesterol transport in athletes. Metabolism, 1993, 42, 684−690.
  • 14. Houot O., Interpretation of Clinical Laboratory Tests (eds. G. Siest, J. Henny, F. Schiele, D.S. young). 1985, Biomedical Publications, p. 250.
  • 15. Jenkins D.J., Kendall C.W., Vidgen E., Agarwal S., Rao A.V., Rosenberg R.S., Health aspects of partially defatted fl axseed, including effects on serum lipids, oxidative measures, and ex vivo androgen and progestin activity: a controlled crossover trial. Am.
  • J. Clin. Nutr., 1999, 69, 395–402. 16. Limaye P.V., Raghuram N., Sivakami S., Oxidative stress and gene expression of antioxidant enzymes in the renal cortex of streptozotocin-induced diabetic rats. Mol. Cell. Biochem., 2003, 243, 147–152.
  • 17. Makni M., Fetoui H., Gargouri N.K., Garoui E.M., Jaber H., Makni J., Boudawara T., Zeghal N., Hypolipidemic and hepatoprotective effects of fl ax and pumpkin seed mixture rich in omega- 3 and omega-6 fatty acids in hypercholesterolemic rats. Food Chem. Toxicol., 2008, 46, 3714–3720.
  • 18. Makni M., Sefi M., Fetoui H., Garoui E., Gargouri K.N., Bouda wara T., Zeghal N., Flax and pumpkin seeds mixture ameliorates diabetic nephropathy in rats. Food Chem. Toxicol., 2010, 48, 2407–2412.
  • 19. Maritim A.C., Sanders R.A., Watkins J.B., Diabetes, oxidative stress and antioxidants. A review. J. Biochem. Mol. Toxicol., 2003, 17, 24–38.
  • 20. Megraw R.E., Dunn D.E., Biggs H.G., Manual and continuousfl ow colorimetry of triglycerols by a fully enzymic method. Clin. Chem., 1979, 25, 273–278.
  • 21. Mohamed D.A., El-Hariri D.M., Al-Okbi S.Y., Impact of feeding bread enriched with fl axseed on plasma profi le of hyperlipidemic rats. Pol. J. Food Nutr. Sci., 2005, 55, 431–436.
  • 22. Oomah B.D., Mazza G., Bioactive components of fl axseed: occurrence and health benefi ts. 2000, in: Phytochemicals and Phytopharmaceuticals (eds. F. Shahidi, C.T. Ho). AOCS Press, Champaign, IL., p. 105.
  • 23. Palanduz S., Ademoglu E., Gokkusu C., Plasma antioxidants and type 2 diabetes mellitus. Res. Commun. Mol. Pathol. Pharmacol., 2001, 109, 309–318.
  • 24. Pegklidou K., Nicolaou I., Demopoulos V.J., Nutritional overview on the management of type 2 diabetes and the prevention of its complications. Curr. Diab. Rev., 2010, 6, 400–409.
  • 25. Prasad K., Oxidative stress as a mechanism of diabetes in diabetic BB prone rats: effect of secoisolariciresinol diglucoside (SDG). Mol. Cell Biochem., 2000, 209, 89–96.
  • 26. Prasad K., Secoisolariciresinol diglucoside from fl axseed delays the development of type 2 diabetes in Zucker rat. J. Lab. Clin. Med., 2001, 138, 32–39.
  • 27. Prasad K., Hypocholesterolemic and antiatherosclerotic effect of fl ax lignan complex isolated from fl axseed. Atherosclerosis, 2005, 179, 269–275.
  • 28. Prasad K., Regression of hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from fl axseed. Atherosclerosis, 2008, 197, 34–42.
  • 29. Pszczola D.E., Genes and diet: the specialized role ingredients may play. Food Tech., 2000, 54, 82–88.
  • 30. Reitman S., Frankel S., Colorimetric methods for aspartate and alanine aminotransferase. Am. J. Clin. Pathol., 1957, 28, 55–60.
  • 31. Rhoads G.G., Gulbrandsen C.L., Kagan A., Serum lipoproteins and coronary artery disease in a population study of Hawaiian Japanese men. New Engl. J. Med., 1976, 294, 293–298.
  • 32. Satoh K., Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clin. Chim. Acta, 1978, 90, 37–43.
  • 33. Schriewer H., Kohnert U., Assmann G., Determination of LDL cholesterol and LDL apolipoprotein B following precipitation of VLDL in blood serum with phosphotungstic acid/MgCl2. J. Clin. Chem. Clin. Biochem, 1984, 22, 35–40.
  • 34. Shah P.K., Kaul S., Nilsson J., Cercek B., Exploiting the vascular protective effects of high-density lipoprotein and its apolipoproteins: an idea whose time for testing in coming. Part I. Circulation, 2001, 104, 2376−2383.
  • 35. Simopoulos A.P., Omega-3 fatty acids in health and disease and in growth and development. Am. J. Clin. Nutr., 1991, 54, 438−463.
  • 36. Stolar M., Addressing cardiovascular risk in patients with type 2 diabetes: focus on primary care. Am. J. Med. Sci., 2011, 341, 132–140.
  • 37. Thompson P.D., Cullinane E.M., Sady S.P., Contrasting effects of testosterone and stanozolol on serum lipoprotein levels. JAMA., 1989, 261, 1165–1168.
  • 38. Toro G., Ackerman P.G., Practical Clinical Chemistry, 1st edition, Little, Brown and Company, Boston USA; 1975, 352–359.
  • 39. Trinder P., Determination of glucose in blood using an oxidaseperoxidase system with a non-carcinogenic chromogen. J. Clin. Path., 1969, 22, 158–161.
  • 40. Ugochukwu N.H., Babady N.E., Cobourne M., Gasset S.R., The effect of Gongronema latifolium extracts on serum lipid profi le and oxidative stress in hepatocytes of diabetic rats. J. Biosci., 2003, 28, 1–5.
  • 41. Vijaimohan K., Jainu M., Sabitha K.E., Subramaniyam S., Anandhan C., Shyamala Devi C.S., Benefi cial effects of alpha linolenic acid rich fl axseed oil on growth performance and hepatic cholesterol metabolism in high fat diet fed rats. Life Sci., 2006, 79, 448−454.
  • 42. Watson D., A simple method for the determination of serum cholesterol. Clin. Chim. Acta, 1960, 5, 637–642.
  • 43. Whitmore C., Type 2 diabetes and obesity in adults. Br. J. Nurs., 2010, 19, 880, 882–886.
  • 44. Young I.S., Lipids for psychiatrists - an overview. J. Psychopharmacol., 2005, 19, 6 Suppl., 66−75.
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