NOD1 and NOD2 receptors: integral members of the innate and adaptive immunity system

• Autorzy: Antosz H. , Osiak M.
• Języki publikacji: EN

Abstrakty

EN

NOD-like proteins (NLR) are a specialized group of intracellular receptors, which constitute an essential component of the host innate immune system. They were discovered more than a decade ago, but research on this particular class of microbial detectors is still ongoing to allow for a better understanding of the mechanisms, recognition of microorganisms, transmission of signals, and carrying out the activation of inflammatory signaling pathways. In this review, we discuss the construction of NOD1 and NOD2 receptors, their functions, and significance in the pathogenesis of inflammatory diseases in humans.

Słowa kluczowe

EN

nucleotide-binding oligomerization domain-containing protein 1 zob.NOD1; NOD1 receptor; NOD2 receptor; immune system; nod gene; NOD-like protein; pathogenesis; human disease; inflammatory disease

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2013
• Tom: 60
• Numer: 3
• Opis fizyczny: p.351-360,fig.,ref.

Twórcy

autor

Antosz H.

• Department of Clinical Genetics, Medical University of Lublin, Lublin, Poland

autor

Osiak M.

• Department of Clinical Genetics, Medical University of Lublin, Lublin, Poland

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