Bcl-2 knockout mice doesn’t produce Bcl-2 protein – one of the major protein factors regulating apoptotic processes involved in development of the nervous system. Bcl-2 deficiency result in increased cell death of motoneurons, sensory and sympathetic neurons (Michaelidis et al. 1996). Only very sparse data on impact of this mutation on motor activity and behavior are available. In the present study we examined the exploratory activity of knockout mice in the open field task, and checked motor related behaviors by means of RotaRod, elevated runway test, strength grip test, and balance rod test. Preliminary data suggest lack of prominent alteration of analyzed parameters, but more experiments are planned to look for possible more subtle changes.