Bovine lactoferrin gene polymorphism and expression in relation to mastiti resistance – a review

• Autorzy: Pawlik A. , Sender G. , Korwin-Kossakowska A.

Warianty tytułu

PL

Związek polimorfizmu i ekspresji genu laktoferyny bydła z występowaniem mastitis

• Języki publikacji: EN

Abstrakty

EN

Lactoferrin is an iron-binding protein present in many mammalian biological fluids, such as tears, saliva and milk, widely investigated due to its multiple activities. Human milk contains 1 to 5 mg of lactoferrin /ml, contrary to bovine milk, where lactoferrin concentration reaches maximum level of 0.1 mg/ml. Dramatic increase of lactoferrin content has been noticed in colostrum, mammary gland secretion during involution, and in milk yielded by females suffering from udder inflammation. Lactoferrin gene has developed during evolutional mutations in transferrin gene. It was mapped to bovine chromosome 22, contains 17 exons and spreads out on about 34.5 kilo base pairs (kbp) of genomic DNA. There are many polymorphisms in lactoferrin gene. Polymorphisms occurring In gene regulatory region seem to be particularly interesting, as they may affect a gene expression. It Has been claimed, that lactoferrin gene expression in mouse and human uterus appeared under estrogen stimulation, but for bovine species the regulation of its expression has not been fully understood yet. Another possibility to find functional polymorphisms is to search for them in exons which code for lactoferrin antimicrobial peptides. Due to its relation to the innate immunity, lactoferrin gene is supposed to be a promising candidate gene for mastitis resistance trait.

PL

Laktoferyna jest białkiem wiążącym żelazo, obecnym w wielu płynach biologicznych ssaków –łzach, ślinie i mleku – szeroko opisanym ze względu na swoje właściwości. W mleku ludzkim znajduje się 1-5 mg laktoferyny, w przeciwieństwie do mleka krowiego, gdzie stężenie tego białka osiąga poziom nie wyższy niż 0,1mg/ml. Gwałtowne zwiększenie ilości laktoferyny następuje w siarze, w wydzielinie wymienia podczas inwolucji oraz w mleku zwierząt cierpiących na zapalenie wymienia. Gen laktoferyny powstał w wyniku ewolucyjnych przemian genu transferyny. Znajduje się w 22 chromosomie bydła, składa z 17 eksonów i zawiera około 34,5 tysiąca par zasad genomowego DNA. Dotychczas wykryto wiele polimorfizmów tego genu. Ciekawe wydają się zwłaszcza jego polimorfizmy występujące w rejonach regulatorowych, z racji ich potencjalnego wpływu na poziom ekspresji. Stwierdzono, że ekspresja genu laktoferyny w macicy ludzkiej i mysiej stymulowana jest przez estrogen, podczas gdy w przypadku bydła,regulacji ekspresji tego genu dotąd nie rozpoznano. Potencjalną możliwością odnalezienia funkcjonalnego polimorfizmu laktoferyny jest poszukiwanie go w eksonach, kodujących przeciwdrobnoustrojowe peptydy tego białka. Z racji związku laktoferyny z odpornością wrodzoną, gen jej uważa się za obiecujący genkandydat odporności krów na mastitis. Powołano się na 56 pozycji piśmiennictwa.

• Wydawca: -
• Czasopismo: Animal Science Papers and Reports
• Rocznik: 2009
• Tom: 27
• Numer: 4
• Opis fizyczny: p.263-271,ref.

Twórcy

autor

Pawlik A.

• Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, 05-552 Wolka Kosowska, Poland

autor

Sender G.

• Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, 05-552 Wolka Kosowska, Poland

autor

Korwin-Kossakowska A.

• Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, 05-552 Wolka Kosowska, Poland

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