Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2013 | 73 | 3 |

Tytuł artykułu

Lesions of the lateral entorhinal cortex disrupt non-spatial latent learning but spare spatial latent learning in the rat (Rattus norvegicus)

Warianty tytułu

Języki publikacji



The current study examined the function of the lateral entorhinal cortex (LEC) in a non-spatial latent learning task and a spatial latent learning task. Latent learning is the acquisition of neutral information that does not immediately influence behavior, but can be recalled and utilized when it becomes relevant to the animal. Based on previous research, it was predicted that the LEC would be necessary for latent learning of non-spatial information, but would not be necessary for latent learning of spatial information. Forty-two male Sprague Dawley rats (Rattus norvegicus) were either given pre- training neurotoxic lesions restricted to the LEC or were given sham (SH) lesions. The rats were then trained and tested on two latent learning tasks: the Latent Cue Preference (LCP) task which assesses single-cue (non-spatial) latent learning and a spatial latent learning task utilizing a Barnes maze. Results showed that rats with LEC lesions were impaired on the non- spatial LCP task compared to SH rats, but showed no impairment on the spatial latent learning task. Therefore, the LEC appears to be selectively involved in processing non-spatial latent learning and does not process, or is at least not necessary for, spatial latent learning. These findings indicate a specific role of the LEC in information processing and provide new information about the function of the entorhinal cortex.

Słowa kluczowe








Opis fizyczny



  • Department of Psychology, Bloomsburg University of Pensylvania, Pensylvania, USA
  • Department of Psychology, Bloomsburg University of Pensylvania, Pensylvania, USA


  • Aggleton JP, Vann SD, Oswald CPJ, Good M (2000) Identifying cortical inputs to the rat hippocampus that subserve allocentric spatial processes: A simple problem with a complex answer. Hippocampus 10: 466-474.
  • Agster KL, Burwell RD (2009) Cortical efferents of the perirhinal, postrhinal, and entorhinal cortices of the rat. Hippocampus 19: 1159-1186.
  • Amaral DG, Witter, MP (1989) The three-dimensional orga¬nization of the hippocampal formation: A review of ana¬tomical data. Neuroscience 31: 571-591.
  • Balińska H (1968) The hypothalamic lesions: Effects on appetitive and aversive behavior in rats. Acta Biol Exp (Warsz) 28: 47-56. Balliene BW, Killcross S (2006) Parallel incentive process¬ing: an integrated view of amygdala function. Trends Neurosci 29: 272-279.
  • Bannerman DM, Rawlins JN, McHugh SB, Deacon RM, Yee BK, Bast T, Zhang WN, Pothuizen HH, Feldon J (2004) Regional dissociations within the hippocampus - memory and anxiety. Neurosci Biobehav Rev 28: 273¬283.
  • Barnes CA (1979) Memory deficits associated with senes¬cence: a neurophysiological and behavioral study in the rats. J Comp Physiol Psychol 93: 74-104.
  • Blodgett HC (1929) The effect of the introduction of reward upon maze performance of rats. Uni Cal Pub Psychol 4: 113-134.
  • Burwell RD (2000) The parahippocampal region: Corticocortical connectivity. Ann N Y Acad Sci 911: 25-42.
  • Cazala P, Bendani T, Zielinski A (1985) Self-stimulation of an 'aversive' brain structure: The mesencephalic central gray area. Brain Res 327: 53-60.
  • Coutureau E, Galani R, Gosselin O, Majchrzak M, Di Scala G (1999) Entorhinal but not hippocampal or subicular lesions disrupt latent inhibition in rats. Neurobiol Learn Mem 72: 143-157.
  • Coutureau E, Lena I, Dauge V, Di Scala G (2002) The ento¬rhinal cortex-nucleus accumbens pathway and latent inhibition: A behavioral and neurochemical study in rats. Beh Neurosci 116: 95-104.
  • Deshmukh SS, Knierim JJ (2011) Representation of non- spatial and spatial information in the lateral entorhinal cortex. Front Behav Neurosci 5: 69.
  • Destrade C, Cazala P (1979) Aversive and appetitive proper¬ties of lateral hypothalamic stimulation in mice. Possible differential effects on long-term memory. Behav Neural Biol 27: 398-412.
  • Eichenbaum H, Lipton PA (2008) Towards a functional orga¬nization of the medial temporal lobe memory system: Role of the parahippocampal and medial entorhinal corti¬cal areas. Hippocampus 18: 1314-1324.
  • Fyhn M, Molden S, Witter MP, Moser EI, Moser MB (2004) Spatial representation in the entorhinal cortex. Science 305: 1258-1264.
  • Gaskin S, White NM (2007) Unreinforced spatial (latent) learn¬ing is mediated by a circuit that includes dorsal entorhinal cortex and fimbria fornix. Hippocampus 17: 586-594.
  • Gaskin S, White NM (2010) Temporary inactivation of the dorsal entorhinal cortex impairs acquisition and retrieval of spatial information. Neurobiol Learn Mem 93: 203¬207.
  • Hafting T, Fyhn M, Molden S, Moser MB, Moser EI (2005) Microstructure of a spatial map in the entorhinal cortex. Nature 436: 801-806.
  • Hargreaves EL, Rao G, Lee I, Knierim JJ (2005) Major dis¬sociation between medial and lateral entorhinal input to dorsal hippocampus. Science 308: 1792-1794.
  • Hiroi N, White NM (1991) The lateral nucleus of the amygdala mediates expression of the amphetamine-pro¬duced conditioned place preference. J Neurosci 11: 2107-2116.
  • Izquierdo I, Medina JH (1993) Role of the amygdala, hip¬pocampus, and entorhinal cortex in memory consolida¬tion and expression. Braz J Med Biol Res 26: 573-589.
  • Izquierdo I, da Silva RC, Bueno e Silva M, Quillfeldt JA, Medina JH (1993) Memory expression of habituation and inhibitory avoidance is blocked by CNQX infused into the entorhinal cortex. Behav Neural Biol 60: 5-8.
  • Jarrard LE, Davidson TL, Bowring B (2004) Functional dif¬ferentiation within the medial temporal lobe in the rat. Hippocampus 14: 434-449.
  • Kerr KM, Agster KL, Furtak SC, Burwell RD (2007) Functional neuroanatomy of the parahippocampal region: the lateral and medial entorhinal areas. Hippocampus 17: 697-708.
  • McDonald AJ, Mascagni F (1997) Projections of the lateral entorhinal cortex to the amygdala: A phaseolus vulgaris leu- coagglutinin study in the rat. Neuroscience 77: 445-459.
  • McDonald RJ, White NM (1995) Hippocampal and nonhip- pocampal contributions to place learning in rats. Behav Neurosci 109: 579-593.
  • Morrison SE, Salzman CD (2010) Re-valuing the amygdala. Curr Opin Neurobiol 20: 221-230.
  • Ortmann R (1985) The conditioned place preference paradigm in rats: Effect of bupropion. Life Sci 37: 2021-2027.
  • Paxinos G, Watson C (2005) The Rat Brain in Stereotaxic Coordinates (5th Ed.). Elsevier Academic Press, San Diego, CA.
  • Pereira P, Ardenghi P, Mello e Souza T, Medina JH, Izquierdo I (2001) Training the step-down inhibitory avoidance task time-dependently increases cAMP-depen¬dent protein kinase activity in the entorhinal cortex. Behavioral Pharmacol 12: 217-220.
  • Salamone JD (1994) The involvement of nucleus accumbens dopamine in appetitive and aversive motivation. Behav Brain Res 61: 117-133.
  • Savage LM, Ramos RL (2009) Reward expectation alters learning and memory: the impact of the amygdala on appetitive-driven behaviors. Behav Brain Res 198: 1-12.
  • Savelli F, Yoganarasimha D, Knierim JJ (2008) Influence of boundary removal on the spatial representations of the medial entorhinal cortex. Hippocampus 18: 1270-1282.
  • Schultz H, Sommer T, Peters J (2012) Direct evidence for domain-sensitive functional subregions in human entorhi¬nal cortex. J Neurosci 32: 4716-4723.
  • Solstad T, Baccara CN, Kropff E, Moster MB, Moser EI (2008) Representation of geometric borders in the entorhinal cortex. Science 322: 1865-1868.
  • Steffenach HA, Witter M, Moser MB, Moser EI (2005) Spatial memory in the rat requires the dorsolateral band of the entorhinal cortex. Neuron 45: 301-313.
  • Stouffer EM (2010) The entorhinal cortex, but not the dorsal hippocampus, is necessary for single-cue latent learn¬ing. Hippocampus 20: 1061-1071.
  • Stouffer EM, Heisey JL (2013) Latent learning of spatial information is impaired in middle-aged rats. Dev Psychobiol 55: 309-315.
  • Stouffer EM, White NM (2005) A latent cue preference based on sodium depletion in rats. Learn Mem. 12: 549¬552.
  • Stouffer EM, White NM (2006) Neural circuits mediating latent learning and conditioning for salt in the rat. Neurobiol Learn Mem 86: 91-99.
  • Stouffer EM, White NM (2007) Roles of learning and moti¬vation in preference behavior:
  • Mediation by entorhinal cortex, dorsal and ventral hip¬pocampus. Hippocampus 17: 147-160.
  • Tolman EC, Honzik CH (1930) Introduction and removal of reward and maze performance in rats. Uni Cal Pub Psychol 4: 257-275.
  • Van Cauter T, Camon J, Alvernhe A, Elduayen C, Sargolini F, Save E (2012) Distinct roles of
  • medial and lateral entorhinal cortex in spatial cognition. Cereb Cortex 23: 451-459.
  • White NM, McDonald RJ (1993) Acquisition of a spatial conditioned place preference is impaired by amygdala lesions and improved by fornix lesions. Behav Brain Res 55: 269-281.
  • White NM, Ouellet MC (1997) Roles of movement and temporal factors in spatial learning. Hippocampus 7: 501-510.


Rekord w opracowaniu

Typ dokumentu



Identyfikator YADDA

JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.