Tubulovesicular structures are present in brains of hamsters infected with the Echigo-1 strain of Creutzfeldt-Jakob disease agent

• Autorzy: Liberski P. P.
• Języki publikacji: EN

Abstrakty

EN

Tubulovesicular structures (particles; TVS) are virion-like particles 25–30 nm in diameter found by thin-section electron microscopy in brains of all prion diseases including scrapie, Creutzfeldt-Jakob disease (CJD), fatal familial insomnia (FFI) and Gerstmann-Sträussler-Scheineker disease (GSS), as well as in cell cultures infected with TSE agents. TVS are regarded as a disease-specific ultrastructural marker for TSEs and, by those not completely satisfied with the prion hypothesis, they are even considered to be a possible candidate for the infectious TSE agent itself. A caveat regarding that interpretation stemmed from previous failures to find TVS by electron microscopic studies of tissues from animals infected with the Echigo-1 strain of CJD agent. We now report detecting TVS in brains of hamsters infected with that strain of CJD agent, albeit with a very low frequency.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2008
• Tom: 68
• Numer: 1
• Opis fizyczny: p.39-42,fig.,ref.

Twórcy

autor

Liberski P. P.

• Laboratory of Electron Microscopy and Neuropathology, Chair of Oncology, Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Lodz, Poland

Uwagi

PL

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