Thalidomide fails to be therapeutic following contusive spinal cord injury in rats

• Autorzy: Reyes-Alva H.J. , Franco-Bourland R. E. , Martinez-Cruz A. , Grijalva I. , Fuchs B. , Madrazo I. , Guizar-Sahagun G.
• Języki publikacji: EN

Abstrakty

EN

Mechanical damage to the spinal cord (SC) generates self-destructive processes that contribute to post-traumatic neurodegeneration. Because thalidomide apparently counteracts these effects its use clinically has been proposed enthusiastically. Nonetheless, we tested its action as a neuroprotectant in a clinically relevant model of SC injury in rats. We administered thalidomide intraperitoneally to rats subjected to thoracic SC contusion as single or repeated doses within the first 24 h after injury. Edema, neutrophil infiltration, and cord tissue preservation/destruction were assessed in the SC 24 h after injury and motor function for 7 weeks. Rats treated with thalidomide showed significant increase in SC water compared with naïve rats, but not vehicle-treated rats; their neutrophil infiltration and amount of spared/destroyed cord tissue was not different from vehicle-treated rats; and in no case was motor performance improved after thalidomide. In conclusion, thalidomide failed here to be therapeutic, discouraging its use clinically for SC trauma.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 4
• Opis fizyczny: p.494–503,fig.,ref.

Twórcy

autor

Reyes-Alva H.J.

• Research Unit for Neurological Diseases, Medical Center Century XXI, Mexican Social Security Institute, Mexico City, Mexico
• Department of Surgery, School of Veterinary Medicine, Autonomous University of the State of Mexico, Toluca, Mexico

autor

Franco-Bourland R. E.

• Department of Experimental Surgery, Camina Project A.C., Mexico City, Mexico
• Department of Biochemistry, National Institute for Rehabilitation, Mexico City, Mexico

autor

Martinez-Cruz A.

• Department of Experimental Surgery, Camina Project A.C., Mexico City, Mexico

autor

Grijalva I.

• Research Unit for Neurological Diseases, Medical Center Century XXI, Mexican Social Security Institute, Mexico City, Mexico
• Department of Experimental Surgery, Camina Project A.C., Mexico City, Mexico

autor

Fuchs B.

• Department of Experimental Surgery, Camina Project A.C., Mexico City, Mexico

autor

Madrazo I.

• Research Unit for Neurological Diseases, Medical Center Century XXI, Mexican Social Security Institute, Mexico City, Mexico
• Department of Experimental Surgery, Camina Project A.C., Mexico City, Mexico

autor

Guizar-Sahagun G.

• Research Unit for Neurological Diseases, Medical Center Century XXI, Mexican Social Security Institute, Mexico City, Mexico
• Department of Experimental Surgery, Camina Project A.C., Mexico City, Mexico

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