PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2015 | 09 | 2 |
Tytuł artykułu

Molecular and environmental aspects of skin cancers

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Skin cancers are one of the most common cancers in the Caucasian population. A constantly increasing number of nonmelanoma skin cancers and malignant melanomas is observed. The incidence of skin cancers is associated mainly with exposure to sunlight. Therefore, agricultural workers who work in open spaces are a particularly vulnerable group. Currently, studies on the pathogenesis of skin cancer focus on the molecular basis associated with ultraviolet radiation. This study is an attempt to summarize the current state of knowledge on this issue. There have been demonstrated mutations in different classes of genes associated with carcinogenesis, including protooncogenes, tumour suppressor genes, genes that control apoptosis, genes encoding transcription factors and DNA repair genes in patients with skin cancers. Mutations in the latter result in reducing the effectiveness of DNA repair and fixation of mutations. All changes at the gene level lead to structural changes, quantitative and dysfunction of proteins encoded by these genes. All these factors contribute to the process of carcinogenesis. Due to increasing number of skin cancers, it seems important to increase knowledge of the molecular basis of skin cancers. This knowledge could be crucial for predicting the course of the disease, and for the development of new therapeutic strategies.
Wydawca
-
Rocznik
Tom
09
Numer
2
Opis fizyczny
p.158-162,fig.,ref.
Twórcy
autor
  • Department of Molecular Biology and Translational Research, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland
autor
  • Department of Molecular Biology and Translational Research, Institute of Rural Health, Lublin, Jaczewskiego 2, 20-090 Lublin, Poland
  • Department of Pathophysiology, Medical University of Lublin, Lublin, Poland
  • Department of Physiopathology, Institute of Rural Health, Lublin, Poland
  • Department of Molecular Biology and Translational Research, Institute of Rural Health, Lublin, Jaczewskiego 2, 20-090 Lublin, Poland
  • Department of Medical Biology and Translational Research, Faculty of Medicine, University of Information Technology and Management, Rzeszów, Poland
Bibliografia
  • 1. Lee CH, Wu SB, Hong CH, Yu HS, Wei YH. Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy. Int J Mol Sci. 2013; 14(3): 6414–6435.
  • 2. Rigel DS. Cutaneous ultraviolet exposure and its relationship to the development of skin cancer. J Am Acad Dermatol. 2008; 58(2): 129–132.
  • 3. Claerhout S, Van Laethem A, Agostinis P, Garmyn M. Pathways involved in sunburn cell formation: deregulation in skin cancer. PhotochemPhotobiol Sci. 2006; 5(2): 199–207.
  • 4. Marek K. Zmiany zawodowe wywołane promieniowaniem jonizującym i elektromagnetycznym. In: Marek K, Kłopotowski JS, editors. Choroby zawodowe. Wydawnictwo Lekarskie PZWL, Warszawa 2003.
  • 5. Narbutt J, Lesiak A, Erkiert A, Sysa-Jedrzejowska A. Non-melanoma skin cancer development and environmental factors. Polish J EnvironStud. 2005; 14: 545–550.
  • 6. Ahmed AH, Soyer HP, Saunders N, Boukamp B, Roberts MS. Nonmelanoma skin cancers. Drug Discov Today Dis Mech. 2008; 5(1): 55–62.
  • 7. Batista LF, Kaina B, Meneghini R, Menck CF. How DNA lesions are turned into powerful killing structures: insights from UV-inducedapoptosis. Mutat Res. 2009; 681(2–3): 197–208.
  • 8. Lauth M, Unden AB, Toftgård R. Non-melanoma skin cancer: pathogenesis and mechanisms. Drug Discov Today Dis Mech. 2004;1(2): 267–272.
  • 9. Jerant AF, Johnson JT, Sheridan CD, Caffrey TJ. Early detection and treatment of skin cancer. Am Fam Physician. 2000; 62(2): 357–68,375–376, 381–382.
  • 10. Mouret S, Baudouin C, Charveron M, Favier A, Cadet J, Douki T. Cyclobutane pyrimidine dimers are predominant DNA lesions in wholehuman skin exposed to UVA radiation. Proc Natl Acad Sci U S A. 2006;103(37): 13765–13770.
  • 11. Setlow RB. DNA repair, aging, and cancer. Natl Cancer Inst Monogr. 1982; 60: 249–255.
  • 12. Ziech D, Franco R, Pappa A, Panayiotidis MI. Reactive oxygen species (ROS) induced genetic and epigenetic alterations in humancarcinogenesis. Mutat Res. 2011; 711(1–2): 167–173.
  • 13. Dixon KM, Tongkao-On W, Sequeira VB, Carter SE, Song EJ, Rybchyn MS et al. Vitamin d and death by sunshine. Int J Mol Sci. 2013; 14(1):1964- 1977.
  • 14. Allain AV, Hoang VT, Lasker GF, Pankey EA, Murthy SN, Kadowitz PJ. Role of nitric oxide in developmental biology in plants, bacteria, andman. Curr Top Pharmacol. 2011; 15(2): 25–33.
  • 15. Hartwell LH, Weinert TA. Checkpoints: controls that ensure the order of cell cycle events. Science 1989; 246(4930): 629–634.
  • 16. Benjamin CL, Melnikova VO, Ananthaswamy HN. P53 protein and pathogenesis of melanoma and nonmelanoma skin cancer. Adv ExpMed Biol. 2008; 624: 265–282.
  • 17. Madan V, Lear JT, Szeimies RM. Non-melanoma skin cancer. Lancet 2010; 375(9715): 673–685.
  • 18. Goodsell DS. The molecular perspective: the ras oncogene. Stem Cells. 1999; 17(4): 235–236.
  • 19. Mellon I, Rajpal DK, Koi M, Boland CR, Champe GN. Transcriptioncoupled repair deficiency and mutations in human mismatch repairgenes. Science 1996; 272(5261): 557–560.
  • 20. Burnworth B, Arendt S, Muffler S, Steinkraus V, Bröcker EB, Birek C et al. The multi-step process of human skin carcinogenesis: a role forp53, cyclin D1, hTERT, p16, and TSP-1. Eur J Cell Biol. 2007; 86(11–12):763–780.
  • 21. Uribe P, Gonzalez S. Epidermal growth factor receptor (EGFR) and squamous cell carcinoma of the skin: molecular bases for EGFR-targeted therapy. Pathol Res Pract. 2011; 207(6): 337–342.
  • 22. Walshe J, Serewko-Auret MM, Teakle N, Cameron S, Minto K et al. Inactivation of glutathione peroxidase activity contributes to UVinducedsquamous cell carcinoma formation. Cancer Res. 2007; 67(10):4751–4758.
  • 23. Nys K, Agostinis P. Bcl-2 family members: essential players in skin cancer. Cancer Lett. 2012; 320(1): 1–13.
  • 24. Thieu K, Ruiz ME, Owens DM. Cells of origin and tumor-initiating cells for nonmelanoma skin cancers. Cancer Lett. 2013; 338(1): 82–88.
  • 25. Athar M, Tang X, Lee JL, Kopelovich L, Kim AL. Hedgehog signalling in skin development and cancer. Exp Dermatol. 2006; 15(9): 667–677.
  • 26. Heitzer E, Lassacher A, Quehenberger F, Kerl H, Wolf P. UV fingerprints predominate in the PTCH mutation spectra of basal cell carcinomasindependent of clinical phenotype. J Invest Dermatol. 2007; 127(12):2872–2881.
  • 27. Heller ER, Gor A, Wang D, Hu Q, Lucchese A, Kanduc D et al. Molecular signatures of basal cell carcinoma susceptibility and pathogenesis: a genomic approach. Int J Oncol. 2013; 42(2): 83–96.
  • 28. Olbryt M. Role of tumor microenvironment in the formation and progression of skin melanoma. Postepy Hig Med Dosw. 2013; 67:413–432.
  • 29. Li G, Satyamoorthy K, Herlyn M. Dynamics of cell interactions and communications during melanoma development. Crit Rev Oral BiolMed. 2002; 13(1): 62–70.
  • 30. Haass NK, Herlyn M. Normal human melanocyte homeostasis as a paradigm for understanding melanoma. J Investig Dermatol SympProc. 2005; 10(2): 153–163.
  • 31. Zigler M, Villares GJ, Dobroff AS, Wang H, Huang L, Braeuer RR et al. Expression of Id-1 is regulated by MCAM/MUC18: a missing link inmelanoma progression. Cancer Res. 2011; 71(10): 3494–3504.
  • 32. Koefinger P, Wels C, Joshi S, Damm S, Steinbauer E, Beham-Schmid C et al. The cadherin switch in melanoma instigated by HGF is mediatedthrough epithelial-mesenchymal transition regulators. Pigment CellMelanoma Res. 2011; 24(2): 382–385.
  • 33. Nys K, Van Laethem A, Michiels C, Rubio N, Piette JG, Garmyn M, et al. A p38(MAPK)/HIF-1 pathway initiated by UVB irradiation is required to induce Noxa and apoptosis of human keratinocytes. J Invest Dermatol. 2010; 130(9): 2269–2276.
  • 34. Lee JT, Herlyn M. Microenvironmental influences in melanoma progression. J Cell Biochem. 2007; 101(4): 862–872.
  • 35. Sendoel A, Kohler I, Fellmann C, Lowe SW, Hengartner MO. HIF- 1 antagonizes p53-mediated apoptosis through a secreted neuronaltyrosinase. Nature 2010; 465(7298): 577–583.
  • 36. Wäster P, Rosdahl I, Gilmore BF, Seifert O. Ultraviolet exposure of melanoma cells induces fibroblast activation protein-α in fibroblasts:Implications for melanoma invasion. Int J Oncol. 2011; 39(1): 193–202.
  • 37. Malak AT, Yildirim P, Yildiz Z, Bektas M. Effects of training about skin cancer on farmers’ knowledge level and attitudes. Asian Pac J CancerPrev. 2011;12(1):117–20.
  • 38. Spiewak R. Pesticides as a cause of occupational skin diseases in farmers. Ann Agric Environ Med. 2001; 8(1): 1–5.
  • 39. Collotta M, Bertazzi PA, Bollati V. Epigenetics and pesticides. Toxicology 2013; 307: 35–41.
  • 40. Jungmann G. Arsenic cancer in vintagers. Landarzt. 1966; 42(28): 1244–1247.
  • 41. Thiers H, Colomb D, Moulin G. Colin L. Arsenical skin cancer in vineyards in the Beaulolais (Fr.). Ann. Dermatol. 1967; 94: 133–158.
  • 42. Kennedy C, Bajdik CD, Willemze R, Bouwes Bavinck JN. Chemical exposures other than arsenic are probably not important risk factors for squamous cell carcinoma, basal cell carcinoma and malignantmelanoma of the skin. Br J Dermatol. 2005; 152(1): 194–197.
  • 43. Mahajan R, Blair A, Coble J, Lynch CF, Hoppin JA, Sandler, DP et al. Carbaryl exposure and incident cancer in the Agricultural Health Study.Int J Cancer. 2007; 121(8): 1799–1805.
  • 44. Purdue MP, Hoppin JA, Blair A, Dosemeci M, Alavanja MC. Occupationalexposure to organochlorine insecticides and cancerincidence in the Agricultural Health Study. Int J Cancer. 2007; 120(3):642–649.
  • 45. Dennis LK, Lynch CF, Sandler DP, Alavanja MC. Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study. Environ Health Perspect. 2010; 118(6): 812–817.
  • 46. Fernandes TR, Santos I, Korinsfky JP, Lima e Silva BS, Carvalho LO, Plapler H. Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide. Acta Cir Bras. 2014; 29(1): 7–15.
  • 47. Pappinen S, Hermansson M, Kuntsche J, Somerharju P, Wertz P, Urtti A, et al. Comparison of rat epidermal keratinocyte organotypic culture (ROC) with intact human skin: lipid composition and thermal phase behavior of the stratum corneum. Biochim Biophys Acta. 2008; 1778(4): 824–834.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-0416eb63-7d6f-4dc7-ae66-a9c2e8393e05
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.