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2017 | 20 | 3 |
Tytuł artykułu

Influence of long-term oral application of quinolones on the ECG curve in dogs

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The aim of the study was to analyse the influence of enrofloxacin and pradofloxacin administered orally for 14 days on the ECG in dogs. The ECG was performed before and after a 14 day period of quinolone administration. There was an increase in the QTc and the TpTe interval in the group treated with quinolones. QTc was prolonged by 24 ms (p=0.001). The TpTe interval was shortened, on average, by 6.55 ms (p=0.048). In the group treated with enrofloxacin, QTc was prolonged by 16.27 ms (p=0.006) and the TpTe interval was shortened by 9.64 ms (p=0.050), the TpTe/QT index was reduced by 0.034 (p=0.050) on average. In dogs treated with pradofloxacin, QTc was prolonged by 21.55 ms (p=0.012) on average. The results suggest that a prolonged administration of quinolones can increase the risk of arrhythmias. Furthermore, different generations of these drugs increase this risk to various degrees. The study proved that second generation quinolones, such as enrofloxacin, significantly change the phase of depolarization and repolarization of the ventricles, at the same time increasing the risk of ventricular arrythmia. Pradofloxacin does not change the TpTe and TpTe/QT values, so it is safer in use.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
20
Numer
3
Opis fizyczny
p.567-572,ref.
Twórcy
autor
  • Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Pl. Grunwaldzki 47, 50-366 Wroclaw, Poland
  • Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Pl. Grunwaldzki 47, 50-366 Wroclaw, Poland
autor
  • Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Pl. Grunwaldzki 47, 50-366 Wroclaw, Poland
autor
  • Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Pl. Grunwaldzki 47, 50-366 Wroclaw, Poland
autor
  • Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Pl. Grunwaldzki 47, 50-366 Wroclaw, Poland
Bibliografia
  • Agudelo-Ramirez CF, Scheer P, Tomenendálová J (2012) Effects of parenteral administration of enrofloxacin on electrocardiographic parameters in hospitalized dogs. Acta Vet Brno 81: 409-414.
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  • Boothe DM, Boeckh A, Boothe HW, Wilkie S (2010) Tissue concentrations of enrofloxacin and ciprofloxacin in anesthetized dogs following single intravenous administration. Vet Therapeutics 2: 120-128.
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  • Chanoit GP, Schneider M, Woehrlé F, Lefebvre HP (2005) Effect of marbofloxacin on cardiovascular variables in healthy isoflurane-anesthetized dogs. Am J Vet Res66: 2090-2094.
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  • Kallergis EM, Goudis CA, Simantirakis EN, Kochiadakis GE, Vardas PE (2012) Mechanisms, risk factors, and management of acquired long QT syndrome: a comprehensive review. Scientific World Journal 2012: 212178.
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  • Toyoshima S, Kanno A, Kitayama T, Sekiya K, Nakai K, Haruna M, Mino T, Miyazaki H, Yano K, Yamamoto K (2005) QT PRODACT: in vivo QT assay in the conscious dog for assessing the potential for QT interval prolongation by human pharmaceuticals. J Pharmacol Sci 99: 459-471.
  • Vormberge T, Hoffmann M, Himmel H (2006) Safety pharmacology assessment of drug-induced QT-prolongation in dogs with reduced repolarization reserve. J Pharmacol Toxicol Methods 54: 130-140.
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
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