PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2011 | 53 | 2 |
Tytuł artykułu

Cytotoxic activity of Paris quadrifolia extract and isolated saponin fractions against human tumor cell lines

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Steroidal saponins isolated from many plant species belonging to Monocotyledones display potent cytotoxic activity towards many human tumor cells. We examined the cytotoxic effects of crude Paris quadrifolia extract for the first time, testing isolated saponin-rich fractions against four different human cell lines using the [(3-(4,5- dimethylthiazol-2-yl)]-2,5-diphenyltetrazolium bromide (MTT) assay. Cytotoxic activity was tested against human promyelocytic leukemia (HL-60) cells, human cervical adenocarcinoma (HeLa) cells and human breast cancer (MDA-MB-468) cells. Human skin fibroblasts were used as non-neoplastic control cells. Our results show significant activity of the weakly water-soluble solid residue and butanolic fraction against HL-60 and HeLa cells. The solid residue exerted cytotoxicity against all tested cell lines.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
53
Numer
2
Opis fizyczny
p.127-131,fig.,ref.
Twórcy
  • Department of Biology and Pharmaceutical Botany, Medical University of Gdansk, Hallera 107, 80-416 Gdansk, Poland
autor
autor
autor
Bibliografia
  • CHEUNG JY, ONG RC, SUEN YK, OOI V, WONG HN, MAK TC, FUNG KP, YU B, and KONG SK. 2005. Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells. Cancer Letters 217: 203–211.
  • CHUNG JW, NOH EJ, ZHAO HL, SIM JS, HA YW, SHIN EM, LEE EB, CHEONG CS, and KIM YS. 2008. Anti-inflammatory activity of prosapogenin methyl ester of platycodin D via nuclear factor-kappaB pathway inhibition. Biological and Pharmaceutical Bulletin 31: 2114–2120.
  • CORBIÉRE C, LIAGRE B, TERRO F, and BENEYTOUT JL. 2004. Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells. Cell Research 14: 188–196.
  • GRUENWALD J, BRENDLER T, and JAENICKE C. 2000. PDR for Herbal Medicines. Medical Economics Company, Montvale, New Jersey.
  • HOSTETTMANN K, and MARSTON A. 1995. Saponins. Cambridge University Press, Cambridge.
  • HOU R, ZHOU QL, WANG BX, TASHIRO S, ONODERA S, and IKEJIMA T. 2004. Diosgenin induces apoptosis in HeLa cells via activation of caspase pathway. Acta Pharmacologica Sinica 25: 1077–1082.
  • HUANG X, KOJIMA-YUASA A, XU S, NORIKURA T, KENNEDY DO, HASUMA T, and MATSUI-YUASA I. 2008. Green tea extract enhances the selective cytotoxic activity of Zizyphus jujuba extracts in HepG2 cells. American Journal of Chinese Medicine 36: 729–744.
  • JUN Z. 1989. Some bioactive substances from plants of West China. Pure and Applied Chemistry 61: 457–460.
  • LEE MS, YUET-WA JC, KONG SK, YU B, ENG-CHOON VO, NAI-CHING HW, CHUNG-WAI TM, and FUNG KP. 2005. Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograft. Cancer Biology and Therapy 4: 1248–1254.
  • LIU MJ, WANG Z, JU Y, WONG RN, and WU QY. 2005. Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis. Cancer Chemotherapy and Pharmacology 55: 79–90.
  • MIMAKI Y, SASHIDA Y, KURODA M, NISHINO A, SATOMI Y, and NISHINO H. 1995. Inhibitory effects of steroidal saponins on 12-O-tetradecanoylphorbol-13-acetate (TPA)-enhanced 32P-incorporation into phospholipids of HeLa cells and proliferation of human malignant tumor cells. Biological and Pharmaceutical Bulletin 18: 467–469.
  • MIMAKI Y, YOKOSUKA A, KURODA M, and SASHIDA Y. 2001. Cytotoxic activities and structure-cytotoxic relationships of steroidal saponins. Biological and Pharmaceutical Bulletin 24: 1286–1289.
  • MOALIC S, LIAGRE B, CORBIÉRE C, BIANCHI A, DAUÇA M, BORDJI K, and BENEYTOUT JL. 2001. A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells. FEBS Letters 506: 225–230.
  • NOHARA T, ITO Y, SEIKE H, KOMORI T, MORIYAMA M, GOMITA Y, and KAWASAKI T. 1982. Study on the constituents of Paris quadrifolia L. Chemical and Pharmaceutical Bulletin 30: 1851–1856.
  • OLESZEK WA. 2002. Chromatographic determination of plant saponins. Journal of Chromatography A 967: 147–162.
  • SHAO Y, POOBRASERT O, KENNELLY EJ, CHIN CK, HO CT, HUANG MT, GARRISON SA, and CORDELL GA. 1997. Steroidal saponins from Asparagus officinalis and their cytotoxic activity. Planta Medica 63: 258–262.
  • TAKHTAJAN A. 1997. Diversity and Classification of Flowering Plants. Columbia University Press, New York.
  • TUTIN TG. 1980. Flora Europaea. Alismataceae to Orchidaceae (Monocotyledones). Cambridge University Press, Cambridge.
  • WANG Z, ZHOU J, JU Y, YAO S, and ZHANG H. 2001. Effects of dioscin extracted from Polygonatum Zanlanscianense Pamp on several human tumor cell lines. Tsinghua Science and Technology 6: 239–242.
  • WOO ER, KIM JM, KIM HJ, YOON SH, and PARK H. 1998. A cytotoxic pennogenin glycoside from Majanthemum dilatatum. Planta Medica 64: 466–468.
  • WU RT, CHIANG HC, FU WC, CHIEN KY, CHUNG YM, and HORNG LY. 1990. Formosanin-C, an immunomodulator with antitumor activity. International Journal of Immunopharmacology 12: 777–786.
  • ZHANG J, MENG Z, ZHANG M, MA D, XU S, and KODAMA H. 1999. Effect of six steroidal saponins isolated from anemarrhenae rhizoma on platelet aggregation and hemolysis in human blood. Clinica Chimica Acta 289: 79–88.
Uwagi
Rekord w opracowaniu
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-036a65e7-fbd7-47f7-93ef-82635b21ae4f
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.