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2015 | 66 | 1 |
Tytuł artykułu

An association between organophosphate pesticides exposure and Parkinsonism amongst people in an agricultural area in Ubon Ratchathani Province, Thailand

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Background. Parkinson’s disease (PD) is a ubiquitous disease. However, PDs prevalence in the population of agricultural communities lacks understanding and there has been no epidemiological study on the association between pesticides exposure factors and risk for PD. Objective. To investigate the potential association between organophosphate pesticides exposure and Parkinsonism by using a screening questionnaire in agricultural areas. Material and Methods. Ninety elderly people living in agricultural areas participated in a cross-sectional study conducted at Tambon Hua-Rua Health Promoting Hospital in April 2014. Screening questionnaires for Parkinson’s disease, Test-mate ChE (Model 400) for blood cholinesterase (ChE) levels of both blood enzymes erythrocyte cholinesterase (AChE), and plasma cholinesterase (PChE) were used as measurement tools. Descriptive statistics for frequencies and percentage distributions were used primarily to summarize and describe the data. Sensitivity, specificity, positive and negative predictive values were calculated. Results. The age range of the participants was 50 to 59 years old, with an average age of 53.9+2.87 years. The majority of the participants were female (62.2%), 82.2% of respondents were farmers. Most of participants (76.7%) reported that they applied insecticides in their farms. Ninety persons participated and completed the 11-item questionnaire. Of these, 17 (18.9%) felt that they lost balance when turning or that they needed to take a few steps to turn right around and 16.7% of participants indicated that they felt the need to move slowly or stiffly. The study found the prevalence of abnormal AChE levels was 28.9% (95%CI=19.81-39.40) and 17.8% of PChE levels (95%CI=10.52-27.26). To predict Parkinsonism, AChE, and PChE level, with a cutoff score of 5 or higher there had to be a sensitivity of 0.31, specificity of 1.00, positive predictive value (PPV) of 1.00 and negative predictive value (NPV) of 0.78 for AChE. While PChE, the score value of 5 or more had a sensitivity of 0.19, specificity of 0.93, PPV of 0.38 and NPV of 0.84. Conclusion. This study described an association between pesticides exposure and Parkinsonism. The questionnaire appears to be useful for Thai agriculturists as a screening tool for Parkinsonism and cholinesterase levels regarding to pesticides exposure.
Wydawca
-
Rocznik
Tom
66
Numer
1
Opis fizyczny
p.21-26,ref.
Twórcy
autor
  • College of Public Health Sciences, Chulalongkorn University, Bangkok, Thailand
  • College of Public Health Sciences, Chulalongkorn University, Bangkok, Thailand
  • Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
autor
  • College of Public Health Sciences, Chulalongkorn University, Bangkok, Thailand
autor
  • College of Public Health Sciences, Chulalongkorn University, Bangkok, Thailand
  • Thai Fogarty ITREOH Center, Chulalongkorn University, Bangkok, Thailand
autor
  • School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, USA
autor
  • Thai Fogarty ITREOH Center, Chulalongkorn University, Bangkok, Thailand
  • School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, USA
Bibliografia
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  • 14. Center NPI. Biomarkers of Exposure: Organophosphates. Available from: http://npic.orst.edu/mcapro/opbiomarkers.html.
  • 15. Diseases BoOaE. Questionnaire for assess the risk of the work of farmers from pesticide exposure. Available from: http://www.envocc.org/downloads/year54/farmer%20assess%20form1_6jan54.pdf
  • 16. Norkaew S, Siriwong W, Siripattanakul S and Robson GM.: Knowledge, Attitude, and Practice (KAP) of Using Personal Protective Equipment (PPE) for Chilli-Growing Farmers in Huarua Sub-District, Mueang District, Ubonrachathani Province, Thailand. J Health Res 2010; 24(2):93-100.
  • 17. Taneepanichskul N, Siriwong W, Siripattanakul S, Pongpanich S and Robson GM.: Risk assessment of chlorpyrifos (organophosphate pesticide) associated with dermal exposure in chilli-growing farmers at Ubonrachatani Province, Thailand. J Health Res. 2010; 24(2):149-56.
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  • 22. Rocca WA, Maraganore DM, McDonnell SK, Schaid DJ.: Validation of a telephone questionnaire for Parkinson’s disease. J Clin Epidemiol 1998; 51(6):517-23.
  • 23. Hunter CB AL, Nashatizadeh MM, Lay LF, Jankovic J.: Evaluation of a Parkinson’s disease screening questionnaire for use in a community-based setting 2008. Available from: https://www.bcm.edu/departments/neurology/cv.cfm?username=chunter.
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Typ dokumentu
Bibliografia
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Identyfikator YADDA
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