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2015 | 18 | 2 |
Tytuł artykułu

Screening method for the determination of tetracyclines and fluoroquinolones in animal drinking water by liquid chromatography with diode array detector

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
A liquid chromatography - diode array detector (HPLC-DAD) procedure has been developed for the determination of oxytetracycline (OTC), tetracycline (TC), chlorotetracycline (CTC), doxycyc-line (DC), enrofloxacin (ENR), ciprofloxacin (CIP), sarafloxacin (SAR) and flumequine (FLU) residues in animal drinking water. This method was applied to animal drinking water. Solid-phase extraction (SPE) clean-up on an Oasis HLB cartridge allowed an extract suitable for liquid chromatographic analysis to be obtained. Chromatographic separation was carried out on a C18 analytical column, using gradient elution with 0.1% trifluoroacetic acid - acetonitrile - methanol at 30oC. The flow-rate was 0.7 mL/min and the eluate was analysed at 330 nm. The whole procedure was evaluated according to the requirements of the Commission Decision 2002/657/EC, determining specificity, decision limit (CCa), detection capacity (CCß), limit of detection (LOD), limit of quantification (LOQ), precision and accuracy during validation of the method. The recoveries of TCs and FQs from spiked samples at the levels of 10, 100 and 1000 ^g/L were higher than 82%. The developed method based on HPLC-DAD has been applied for the determination of four tetracyclines and four fluoroquinolones in animal drinking water samples.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
18
Numer
2
Opis fizyczny
p.283-289,fig.,ref.
Twórcy
autor
  • Department of Hygiene of Animal Feedingstuffs, National Veterinary Research Institute, 24-100 Pulawy, Poland
autor
  • Department of Hygiene of Animal Feedingstuffs, National Veterinary Research Institute, 24-100 Pulawy, Poland
autor
  • Department of Hygiene of Animal Feedingstuffs, National Veterinary Research Institute, 24-100 Pulawy, Poland
  • Department of Hygiene of Animal Feedingstuffs, National Veterinary Research Institute, 24-100 Pulawy, Poland
autor
  • Department of Hygiene of Animal Feedingstuffs, National Veterinary Research Institute, 24-100 Pulawy, Poland
Bibliografia
  • Babić S, Asperger D, Mutavdzič D, Horvat AJ, Kastelan-Macan M (2006) Solid phase extraction and HPLC detremination of veterinary pharmaceuticals in waste-water. Talanta 70: 732-738.
  • Brown SA (1996) Fluoroquinolones in animal health. J Vet Pharmacol Ther 19 : 1-14.
  • Charlet M, Schelkens M, Croubels S, De Backer P (2003) Quantitative multi-residue analysis of tetracyclines and their 4-epimers in pig tissues by high-performance liquid chromatography combined with positive-ion electros-pray ionization mass spectrometry. Anal Chim Acta 492: 199-213.
  • Denooz R, Charlier C (2008) Simultaneous determination of five ß-lactam antibiotics (cefepime, ceftazidime, cefuroxime, meropenem and piperacillin) in human plasma by high-performance liquid chromatography with ultraviolet detection. J Chromatogr B 864: 161-167.
  • Esponda S, Torres Padron ME, Ferrera Z, Santana Rodrigez JJ (2009) Solid-phase microextraction with micellar desorption and HPLC-fluorescence detection for the analysis of fluoroquinolones residues in water samples. Anal Bioanal Chem 394: 927-935.
  • Gajda A, Posyniak A, Żmudzki J, Tomczyk G (2013) Determination of doxycycline in chicken fat by liquid chromatography with UV detection and liquid chromatography-tandem mass spectrometry. J Chromatogr B 928: 113-120.
  • Garcia-Mayor MA, Garcinuno RM, Fernandez-Hernando P, Durand-Alegria JS (2006) Liquid chromatography - UV diodearray detection method for multi-residue determination of macrolide antibiotics in sheep's milk. J Chromatogr A 1122: 76-83.
  • Grandos M, Encabo M, Compano R, Pratt MD (2005) Determination of tetracyclines in water samples using liquid chromatography with fluorimetric detection. Chromatog-raphia 61: 471-477.
  • Hernandez M, Borrull F, Calull M (2000) Determination of quinolones in plasma samples by capillary electrophoresis using solid-phase extraction. J Chromatogr B 742: 255-265.
  • Hernandez M, Aguilar C, Borrull F, Calull M (2002) Determination of ciprofloxacin, enrofloxacin and flumequine in pig plasma samples by capillary isotachophoresis-capil-lary zone electrophoresis. J Chromatogr B 772: 163-172.
  • Hirsch R, Terens TA, Haberer K, Mehlich A, Ballwanz F, Kratz KL (1998) Determination of antibiotics in different water compartments via liquid chromatography-elec-trospray tandem mass spectrometry. J Chromatogr A 815: 213-223.
  • Jia A, Xiao Y, Hu J, Asami M, Kunikane S (2009) Simultaneous determination of tetracyclines and their degradation products in environmental waters by liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr A 1216: 4655-4662.
  • Kamel AM, Brown PR, Munson B (1999) Effects of Mobile-Phase Additives, Solution pH, Ionization Constant, and Analyte Concentration on the Sensitivities and Elec-trospray Ionization Mass Spectra of Nucleoside Antiviral Agents. Anal Chem. 71: 5481-5492.
  • Lindsey ME, Meyer M, Thurman EM (2001) Analysis of Trace Levels of sulfonamide and Tetracycline Antimicrobials in Groundwater and Surface Water Using Sol-ide-Phase Extraction and Liquid Chromatography/Mass Spectrometry. Anal Chem 73: 4640-4646.
  • Lillenberg M, Yurchenko S, Kipper K, Herodes K, Pihl V, Sepp K, Lohmus R, Nei L (2009) Simultaneous determination of fluoroquinolones, sulfonamides and tetracyc-lines in sewage sludge by pressurized liquid extraction and liquid chromatography electrospray ionization-mass spectrometry. J Chromatogr A 1216: 5949-5954.
  • Martinez M, McDermott P, Walker R (2006) Pharmacology of the fluoroquinolones: a perspective for the use in domestic animals. Vet J 172: 10-28.
  • Miao XS, Koening BG, Metcalfe CD (2002) Analysis of acidic drugs in the effluents of sewage treatment plants using liquid chromatography-electrospray ionization tandem mass spectrometry. J Chromatogr A 952: 139-147.
  • Moeder M, Schrader S, Winkler M, Popp P (2000) Solid-phase microextraction-gas chromatography-mass spectrometry of biologically active substances in water samples. J Chromatogr A 873: 95-106.
  • Nozal L, Arce L, Simont BM, Rios A, Valcarcel M (1995) Rapid determination of trace levels of tetracyclines in surface water using a continuous flow manifold coupled to a capillary electrophoresis system. In: Oka H, Nakazawa H, Harada KI, MacNeil JD (eds) Chemical Analysis for Antibiotics Used in Agriculture. AOAC Inter Arlington, USA, pp. 333.
  • Patyra E, Kowalczyk E, Kwiatek K (2014) Screening method for the detemination of selected tetracyclines in water by liquid chromatography with diode array detector. Bull Vet Inst Pulawy 58: 65-70.
  • Ramos M, Aranda A, Garcia E, Reuvers T, Hooghuis H (2003) Simple and sensitive determination of five quinolones in food by liquid chromatography with fluorescence detection. J Chromatogr B 789: 373-381.
  • Schnappinger D, Hillen W (1996) Tetracyclines: antibiotic action, uptake, and resistance mechanisms. Arch Microbiol 165: 359-369.
  • Seifertova M, Pena A, Lino CM, Solich P (2008) Determination of fluoroquinolone antibiotics in hospital and municipal wastewater in Coimbra by liquid chromatography with a monolithic column and fluorescence detection. Anal Bioanal Chem 391: 799-805.
  • Tong J, Rao Q, Zhu K, Jiang Z, Ding S (2009) Simultaneous determination of five tetracycline and macrolide antibiotics in feeds using HPCE. J Sep Sci 32: 4254-4260.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-03349a08-9c58-46fd-8a49-c394ccb8f838
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