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2017 | 63 | 4 |
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8-Prenylnaringenin from hop (Humulus lupulus L.) – a panacea for menopause?

Treść / Zawartość
Warianty tytułu
PL
8-Prenylnaringenina z szyszek chmielu (Humulus lupulus L.) – panaceum na menopauzę?
Języki publikacji
EN
Abstrakty
EN
8-Prenylnaryngenin (8-PN) is the strongest known phytoestrogen (PE). Its main source is the female inflorescences of hops (Humulus lupulus L.). 8-PN, which, in contrast to other PEs, is proven to have stronger activity and higher affinity for the α subtype of estrogen receptor (ER). Therefore, it may be an effective substitute for hormone replacement therapy (HRT). The studies in postmenopausal women have shown its particular effectiveness in reducing hot flashes. However, a strong stimulation of uterus by 8-PN may be associated with the occurrence of adverse effects (eg. bleeding) and increase the risk of carcinogenesis. The H. lupulus extracts preparations are currently supplements which makes control of the doses used and thus increases the occurrence of uncontrolled self-treatment difficult. This paper presents the current knowledge on 8-PN and discusses the potential risks associated with use of hops to alleviate the symptoms of menopause.
PL
8-Prenylonaryngenina (8-PN) jest najsilniejszym znanym fitoestrogenem. Jej głównym źródłem są żeńskie kwiatostany (szyszki) chmielu Humulus lupulus L. W odróżnieniu od innych fitoestrogenów, 8-PN charakteryzuje się większą aktywnością i silniejszym powinowactwem wobec podtypu α receptorów estrogenowych (ER), dlatego może stanowić skuteczny zamiennik hormonalnej terapii zastępczej (HTZ). Badania z udziałem kobiet w okresie postmenopauzalnym dowiodły skuteczności 8-PN zwłaszcza w łagodzeniu uderzeń gorąca, jednak silna stymulacja macicy może prowadzić do efektów ubocznych (np. krwawień) i zwiększać ryzyko nowotworzenia. Preparaty z ekstraktem z chmielu mają status suplementów, co utrudnia precyzyjne określenie stosowanych dawek i prowadzi do niekontrolowanego samoleczenia. Artykuł prezentuje bieżącą wiedzę na temat 8-PN i omawia potencjalne ryzyko związane z używaniem chmielu do łagodzenia objawów menopauzy.
Wydawca
-
Czasopismo
Rocznik
Tom
63
Numer
4
Opis fizyczny
p.34-44,fig.,ref.
Twórcy
autor
  • Department of Pharmacognosy and Phytochemistry, School of Pharmacy with Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Jagiellonska 4, 41-200 Sosnowiec, Poland
autor
  • Department of Pharmacognosy and Phytochemistry, School of Pharmacy with Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Jagiellonska 4, 41-200 Sosnowiec, Poland
  • Department of Pharmacognosy and Phytochemistry, School of Pharmacy with Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Jagiellonska 4, 41-200 Sosnowiec, Poland
Bibliografia
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Typ dokumentu
Bibliografia
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Identyfikator YADDA
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