West Bengal is one of the most populated states of India. The residents of the state are mostly dependent on agriculture and allied activities for their livelihood. Livestock also provide economic support and food security to them. A survey in veterinary hospitals and cattle farms of Murshidabad, Nadia, Malda and Birbhum district of West Bengal indicated the frequent occurrence of bacterial, fungal, viral and protozoan diseases in cattle. Some of these diseases like cryptosporidium diarrhoea, ringworm and salmonelliasis are zoonotic in nature and thus, are easily transmitted to human. The frequency of diseases increases during rainy season. Infection of alimentary canal and pneumonia are more common in calves whereas, arthritis is more common in male. Most of the common diseases of cattle like anthrax, rabies, foot and mouth disease, bovine tuberculosis, etc., can be prevented by proper vaccination. Some of these diseases can easily be diagnosed by modern techniques like ELISA, PCR, etc. But lack of veterinary hospitals, socio-economic backwardness and misconception have prevented easy diagnosis and treatment of these common diseases. Common antibiotic like kanamycin, antifungal drugs and antitoxins are generally applied to treat these diseases. Further, maintenance of proper hygiene, isolation of diseased animal, regular check-up and vaccination can prevent easy transmission of the diseases and thus, will put a check on livestock damage.