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2017 | 77 | Suppl.1 |
Tytuł artykułu

Kernel current source density and connectivity estimation methods for the analysis of local field potentials

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
INTRODUCTION: Extracellular potentials, such as the Local Field Potentials (LFPs), are routinely measured in numerous electrophysiological experiments. LFP can carry valuable information about the electric properties of the tissue, however analysis of the recorded signal is usually a complex task. Apart from basic preparation, such as bandpass filtering and artifact removal, many other analytic methods have been proposed for the LFP study. Here we discuss methods for estimation of electric sources and sinks in brain tissue (Current Source Density, CSD) and methods to estimate connectivity in small networks, and their utility in analysis of cortical recordings in rats. AIM(S): Comparison of the effective connectivity and the structure of sinks and sources in cortical columns during whisker stimulations. METHOD(S): Analytic methods: kernel Current Source Density and Modular Connectivity Factorization (MCF) applied to LFP recordings and simulated data from cortical column. Experimental methods: Simultaneous multielectrode in vivo recordings from both hemispheres of the rats brain. RESULTS: Preliminary studies show different distribution of the current sources in contralateral to ipsilateral hemisphere during whisker stimulation in rats. Comparison of the hemispheres from deprived rats shows an extension of the whisker representation in the barrel cortex receptive field. CONCLUSIONS: KCSD method showssignificant differences in current sources localization in contralateral to ipsilateral hemisphere. Modular Connectivity Factorization method applied to LFP recordings from simulated data separates cortical column layers into interpretable modules. Physiological interpretation of the results needs further validation on the cortical column model. FINANCIAL SUPPORT: Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polska Akademia Nauk, Warsaw, Poland, Uniwersytet Warszawski, Warsaw, Poland
Słowa kluczowe
Wydawca
-
Rocznik
Tom
77
Numer
Opis fizyczny
p.130-131
Twórcy
autor
  • Department of Neurophysiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
  • Instytut Zoologii, Wydział Biologii, University of Warsaw, Warsaw, Poland
autor
  • Instytut Zoologii, Wydział Biologii, University of Warsaw, Warsaw, Poland
autor
  • Instytut Zoologii, Wydział Biologii, University of Warsaw, Warsaw, Poland
autor
  • Instytut Zoologii, Wydział Biologii, University of Warsaw, Warsaw, Poland
autor
  • Department of Neurophysiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-01177e47-9393-474f-a6f3-45f0047643a0
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