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2017 | 77 | 2 |

Tytuł artykułu

Dichlorodiphenyltrichloroethane (DDT) induced extracellular vesicle formation: a potential role in organochlorine increased risk of Parkinson’s disease

Warianty tytułu

Języki publikacji



A number of studies have demonstrated that rural living and exposure to pesticides such as dichlorodiphenyltrichloroethane (DDT) highly increase the chances of developing Parkinson’s disease. In a previous work, we have found that DDT leads to the formation of vesicular buds that are released from the cells upon fusion of an intermediate endocytic compartment with the plasma membrane. Since extracellular vesicles like exosomes have been implicated in the development of neurodegenerative diseases through the propagation of neurotoxic misfolded proteins from neuron to neuron, in this minireview we propose that organochlorine pesticides could enhance the risk of neurodegenerative diseases by increasing the formation of exosomes.

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Opis fizyczny



  • Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA
  • Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
  • Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
  • Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
  • Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy


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