Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
1989 | 40 | 5-6 |

Tytuł artykułu

Effect of cadmium intoxication on glucose utilization in energy metabolism of muscles

Treść / Zawartość

Warianty tytułu

Języki publikacji



Kielan, Z., Ziółkowska, B., Falkus, B. and Jethon, Z.: Effect of cadmium intoxication on glucose utilization in energy metabolism of muscles. Acta physiol, pol., 1989,40(5-6): 535-543. The influence of cadmium intoxication on carbohydrate metabolism in skeletal muscles and liver of the male Wistar rats has been studied. Cadmium was administered as cadmium acetate in a dose of 0.3 mg Cd² /kg body weight for three months. At the same time the control rats were injected with 0.9% NaCl. The animals were decapitated and samples of their skeletal muscles: the soleus muscle (composed mainly of red slow twitch fibers; ST) the gastrocnemius muscle containing two types of fibers (white fast twitch fibers FTb and red fast twitch fibers, FTa) and the liver were dissected out. In the samples of muscles, liver and serum contents of glycogen, glucose, pyruvate and lactate, as well as activities of hexokinase, pyruvate kinase and lactate dehydrogenase were measured. Intoxication of rats with cadmium for three months resulted in a reduction of glycolytic enzymes in the serum, ST and FTa muscle fibers and in the liver but did not change the activities of glycolytic enzymes in the FTb muscle fibers. The data obtained for the concentrations of glycogen in the liver and skeletal muscles suggest different mechanisms of cadmium influence on glycogen utilization in these organs.

Słowa kluczowe








Opis fizyczny



  • Department of Human of Animal Physiology, Silesian School of Medicine, Katowice, Poland
  • Department of Human of Animal Physiology, Silesian School of Medicine, Katowice, Poland
  • Department of Human of Animal Physiology, Silesian School of Medicine, Katowice, Poland
  • Department of Human of Animal Physiology, Silesian School of Medicine, Katowice, Poland


  • 1. Chapatwala, K.D., Rajanna, В., Desaiah, D. (1980) Cadmium induced changes in gluconeogenic enzymes in rat kidney and liver. Drug Chem. Toxicol. 3. 407-420.
  • 2. Dobryszycka, W., Owczarek, H. (1981) Effects of lead, copper and zinc on the rats lactate dehydrogenase in vivo and in vitro. Arch. Toxicol. 48. 21-27.
  • 3. Ithakissios, D. S., Chafghazi, T., Mennear, J. H., Kessler, W. V. (1975) Effect of multiple doses of cadmium on glucose metabolism and insulin secretion in the rat. Toxicol. Appl. Pharmacol. 31. 143-149.
  • 4. Kotsonis, F. N., Klaassen, C. D. (1970) Toxicity and distribution of cadmium administrated to rats at sublethal doses. Toxicol. Appl. Pharmacol. 41. 667-680.
  • 5. Me Lane, J. A., Holloszy, J. O. (1979) Glycogen synthesis from lactate in the three types of skeletal muscle. J. Biol. Chem. 14. 6548-6553.
  • 6. Marali, Z., Kacew, S., Singhal, R. L. (1975) Response of hepatic carbohydrate and cAMP metabolism to cadmium treatment in rats. Can. J. Pharmacol. 53. 174-184.
  • 7. Merali, Z., Singhal, R. L. (1980) Diabetogenic effect of chronic oral cadmium administration to neonatal rats. Brit. J. Pharmacol. 69. 151-157.
  • 8. Merck, E. A. G. (1962) Medizinisch-chemische Untesuchungsmetoden. Verlag Chemie GMBH, Weinheim, pp. 150.
  • 9. Muller, L. (1984) Differential sensitivity of integrity criteria as indicators of cadmium-induced cell damage. Toxicol. Lett. 21. 21-27.
  • 10. Nakamura, K., Nishiyama, S., Takata, T., Suzuki, E., Sugiura, Y., Kobayashi, T., Chao, B. (1983) Effects of zinc on cadmium-induced alterations in hepatic functions and blood glucose of rats. Environ. Res. 30. 175-181.
  • 11. Prasada Rao, P. V. V., Gardner, D. E. (1986) Effects of cadmium inhalation on mitochondrial enzymes in rat tissues. J. Toxicol., Environ. Health 17. 191-199.
  • 12. Rajanna, B., Fikes, E., Simpson, H., Chapatwala, K. D., Hobson, M. (1985) Reversibility effects on renal and hepatic gluconeogenic enzymes in rats from chronic exposure of cadmium. J. Toxicol. Environ. Health 15. 521-529.
  • 13. Singhal, R. M., Merali, Z., Kacew, S., Sutherland, D. J. B. (1974) Persistence of cadmium-induced metabolic changes in liver and kidney. Science 183. 1094-1096.
  • 14. Strom, B. (1949) The influence of anoxia on lactate utilization in man after prolonged muscular work. Acta. Physiol. Scand. 17. 440-444.
  • 15. Szczeklik, E. (1974) Enzymologia kliniczna. PZWL, Warszawa, pp. 262; 268.
  • 16. Tolbert, M. E. M., Kamalu, J. A., Draper, G. D. (1981) Effects of cadmium, zinc, copper and manganese on hepatic parenchymal cell gluconeogenesis. Environ. Sci. Health B16 (5). 575-585.
  • 17. Toury, R., Stely, N., Boissonneau, E., Dupuis, Y. (1985) Degenerative processes in skeletal muscle of Cd²⁺- treated rats and Cd²⁺ inhibition of mitochondrial Ca²⁺ transport. Toxicol. Appl. Pharmacol. 77. 19-35.
  • 18. Toury, R., Boissonneau, E. Stelly, N., Dupuis, Y., Berville, A., Perasso, R. (1985a) Mitochondria alterations in Cd²⁺ - treated rats: General regression of inner membrane cristae and electron transport impairment. Biol. Cell. 55. 71-86.
  • 19. Wróblewski, F., La Due, J. S. (1955) Lactic dehydrogenase activity in blood. Proc Soc. Exp. Biol. 90. 210-216.
  • 20. Vallee, B. L., Ulmer, D. D. (1972) Biochemical effects of mercury, cadmium and lead. Ann. Rev. Biochem. 41. 91-128.
  • 21. Żak, J., Steibert, E. (1980) Biochemiczne aspekty toksykologii kadmu. Post. Hig. Med. Dośw. 34. 249-272.

Typ dokumentu



Identyfikator YADDA

JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.