Hemorrhaging from large vessels poses a serious problem in emergency situations when blood loss needs to be immediately controlled. The aim of the study was to compare the effectiveness of two hemostatic dressings in controlling bleeding from a surgically punctured femoral artery. The study was performed on thirteen pigs divided into two groups, of six and seven pigs, respectively. Combat gauze covered with ChitoClear hqg 95 chitosan and Protanal LF10/60 FT sodium alginate was used in the first group, seton covered with identical substances was uses in the second group. Selected hemostatic dressing was applied to the wound 20 seconds after incision and then removed at regular time intervals to evaluate hemostasis. Modified seton was characterized by a shorter time to hemostasis than combat gauze. The result of this experiment indicate that modified seton proved to be a more effective dressing than modified combat gauze.